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Psoriatic arthritis is a joint disease developed by and estimated 20 to 40 percent of psoriasis patients. Detecting the disease in the early stages can provide an opportunity to administer treatments that can lessen the damage to the joints. Pharmaceutical company PharmaGenoma, through its subsidiary PsoriasisDx, has developed a genetic test to assist [...] Gout is a painful condition which results from high levels of uric acid in the blood. Over time the uric acid forms crystals in the joints which leads to inflammation, stiffness and pain. Normally, the kidneys remove uric acid from the blood and eliminate it in urine. But the kidneys in those with gout [...] Like all aspects of the development of the human body, genetics dictate each individual’s height. Last year a team of researchers identified the initial common gene that influences height. That same team has now identified 20 additional genetic regions that can collectively influence height differences of almost 2.5 inches. According to the research team, [...] Tumor necrosis factor (TNF) has been identified as having a key responsibility in many inflammatory diseases, including rheumatoid arthritis (RA). There has been substantial research into the early signaling pathways activated by TNF, but there is not much known about the delayed and chronic TNF responses. In addition, cells called macrophages (cells within the [...] A global team of researchers, led by Professor Matthew Brown, from the University of Queensland’s Diamantina Institute for Cancer, Immunology and Metabolic Medicine, has discovered that there is a genetic relationship between ankylosing spondylitis (AS) and Crohn’s disease. The study was published in the current issue of Nature Genetics. AS is a form of [...] I have posted in the past about the links discovered between various forms of arthritis and genetics. Here are a couple more genes that have been identified with an increased risk in arthritis. HLA-B27 The first gene, HLA-B27, was determined in the 1960’s to have a link with spondyloarthropathies, which are a group of [...] The Arthritis Foundation recently came out with its list of the top 10 arthritis events for the year 2007. This series will focus on those events. #4: Identification of RA Susceptibility Genes STAT4 and TRAF1-C5 Genetic researchers have been able to perform evaluations of variations in DNA. One of the areas of research that [...] |
  
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