free counters

Arthritis Primer

Arthritis is the name for a group of conditions that exhibit damage to joints such as knees, hips and fingers. According to the Arthritis Foundation there are over 100 different conditions covered by the term “arthritis”, the most common being osteoarthritis and rheumatoid arthritis.

Depending of the form of arthritis the initial symptoms of are pain and stiffness which can occur after resting (morning) or at the end of the day. Additional symptoms can include rash, fever, swelling, muscle pain, eye pain and mouth ulcers.

Osteoarthritis (OA), also known as degenerative arthritis, degenerative joint disease and arthrosis, is a condition caused by the protective cartilage that protects the ends of bones gradually breaks down. Research indicates that up to 60% of osteoarthritis cases are hereditary. It can also result from injury, obesity (additional weight on joints), inflammatory diseases, diabetes and hormonal disorders. The weight bearing joints – hips, knees and back – are most commonly affected. It is not uncommon for the joints of the feet and hands to also be affected. OA affects nearly 21 million people in the United States, accounting for 25% of visits to primary care physicians. It is estimated that 80% of the population will have some evidence of OA by age 65.

osteoarthritis image

Rheumatoid arthritis is a chronic, autoimmune disease characterized by inflammation of the synovium, or lining, of the joints. This means that the body’s immune system incorrectly identifies the synovium as a foreign material and attacks it. This results in swelling and inflammation of the joint which, in turn, causes tissue and cartilage damage around the joint.

rheumatoid arthritis image

Unfortunately, people of all ages can develop rheumatoid arthritis. Researchers have discovered many potential causes, including emotional or physical stress, bacterial infections, poor nutrition or genetics.

There are several tests that are used to diagnose rheumatoid arthritis. A blood test is used to check for the presence and level of inflammation in the body. Radiographic imaging (X-rays), magnetic resonance imaging (MRI) scans and bone scans will provide visual indications of the severity and progression of arthritis in the joints.

Following a positive diagnosis for RA, there are a number of treatment options available to slow the progression of the disease, improve the pain and maintain mobility. These treatments include several classes of drug therapies, whirlpool treatments, physical therapy and exercises to increase mobility and prevent complications.

There are also many natural treatments that can be utilized. Certain foods contain anti-inflammatory properties, such as pineapple and tart red cherries. Other foods contribute to repairing and rebuilding bone and cartilage, such as eggs, asparagus, onions and garlic. Many other foods are believed to have beneficial effects on rheumatoid arthritis symptoms. These include fish, brown rice, non-acidic fresh fruits, oatmeal, and leafy green vegetables.

Research indicates that food allergies may be linked to rheumatoid arthritis. People with rheumatoid arthritis were found to have higher antibody levels in their intestinal fluid to proteins from hen’s eggs, pork, cow’s milk, codfish and cereal than that of people without RA.

In addition, many people with back and neck pain report that they have experienced pain relief when they eliminated foods that they were allergic to.

Exercise is highly recommended for improving the symptoms of RA. Strengthening the muscles, which can contribute to a reduction of stress on the joints, leads to improved strength of the bones and improvement in the flexibility and health of the cartilage. Exercises, such as swimming or walking, are excellent ways to slow the progression of the disease.

Obesity is another common contributor to arthritis. Weight loss is one of the best ways to improve the symptoms of arthritis.

Arthritis is a serious condition. If you think that you may have arthritis, you should confer with your doctor for a diagnosis.

GD Star Rating
loading...

Originally posted 2009-07-09 17:30:07. Republished by Blog Post Promoter

New Scan for Early Diagnosis of Osteoarthritis

Osteoarthritis is the “wear and tear” form of arthritis. It results from a breakdown of cartilage that protects the ends of the bones. Osteoarthritis is most common in the hip and knee and is the most frequent reason for total knee and hip replacement surgery.

The current methods used to diagnose osteoarthritis are ineffective prior to an advanced stage where permanent joint damage has occurred. Being able to diagnose osteoarthritis at an earlier stage could provide an opportunity to reduce or prevent permanent damage. Early in the disease it may be possible to successfully treat it with dietary supplements and medications.

Now NYU researchers Alexej Jerschow, Ph.D. and Ravinder R. Regatte, Ph.D. have developed a new scan that may provide that hoped for early diagnosis.

This new test is based on a modified form of magnetic resonance imaging (MRI). This imaging identifies the concentration of glycosaminogycan (GAG), a polymer that holds water and gives cartilage its toughness and elasticity. According to Jerschow, a low concentration of GAG is known to correlate with the inception of osteoarthritis and other cartilage disorders.

“Our methods have the potential of providing early warning signs for cartilage disorders like osteoarthritis, thus potentially avoiding surgery and physical therapy later on,” states Jerschow. “Also, the effectiveness of early preventative drug therapies can be better assessed with these methods.”

The new imaging “tags” the hydrogen atoms that are attached to the GAGs to determine the concentration of GAG in the cartilage.

“Given the lack of knowledge about OA, I think any method that is noninvasive and relatively easy to apply will be quite valuable. Not only do you address diagnosis, but you address how we can understand OA’s mechanism,” says Jerschow.

The new test could also be used to determine the efficacy of the medications used to treat osteoarthritis. In fact, pharmaceutical companies have already requested information on using the new imaging to show that their drugs work.

According to Dr. Regatte, the time and cost for the GAG scan is essentially the same as a normal MRI. It is even possible to get a diagnosis on the same day.

Drs. Jerschow and Regatte presented their findings on August 21st at the 236th National Meeting of the American Chemical Society in Philadelphia.

GD Star Rating
loading...

Originally posted 2008-09-02 19:51:56. Republished by Blog Post Promoter

Rheumatoid Arthritis: Anti-TNF vs. DMARDS

Several studies have been conducted into to effectiveness of the newest class of drugs, tumor necrosis factor (TNF)-alpha blockers, in treating rheumatoid arthritis. But there have been no published studies comparing TNF-alpha blockers with the older class of drugs, known as disease-modifying anti-rheumatic drugs (DMARDS), such as Remicade (infliximab), Enbrel (etanercept), and Humira (adalimumab).

Recently a team of Spanish researchers, led by Dr Alberto Alonso-Ruiz has reviewed the findings of 13 clinical trials involving over 7,000 participants to compare anti-TNF to DMARDS. The team analyzed the data to determine the benefits and side effects of different doses of the drugs.

The team determined that all of the trials showed that, with the proper dose, anti-TNF were better for treating rheumatoid arthritis than drugs like methotrexate.

The research also pointed out, however, that those patients using anti-TNF drugs were more likely to complain of adverse side effects. In addition, patients that were using etanercept experienced the lowest withdrawal rates due to adverse events.

“Performing comparisons of new drugs is vital for measuring safety/efficacy relationships and monitoring adverse side-effects” said Dr. Alonzo-Ruiz.

Their research was published in the journal BMC Musculoskeletal Disorders.

GD Star Rating
loading...

Originally posted 2008-05-02 15:36:39. Republished by Blog Post Promoter

Pfizer Settles Bextra, Celebrex Lawsuits

As a follow up to the last post, Pfizer announced last Friday that they have agreed to pay $894 million to settle 3 lawsuits that alleged Celebrex and Bextra harmed patients in the U.S. and defrauded consumers. The suits claimed that Bextra and Celebrex resulted in increased risks of heart attacks and strokes.

There were rumors as early and May 2008 of a settlement. At that time the Wall Street Journal reported that attorneys for Pfizer were in negotiations with representatives of the plaintiffs. Pfizer did not confirm the settlements until the press release issued last week.

Of the $894 settlement, $745 million will go toward settling injury claims, $89 million for Bextra and Celebrex class action consumer fraud suits, and $60 million for state attorney general settlements over marketing practices related to Bextra.

The U.S Food and Drug Administration (FDA) asked Pfizer to withdraw Bextra in 2005, less than 4 years after its approval by the FDA. This was due to mounting evidence of increased cardiovascular risks and reports of a potentially fatal skin reaction called Stevens-Johnson syndrome.

Bextra and Celebrex are in the same class of drugs as Vioxx, which was previously withdrawn from the market in September 2004. Merck, the maker of Vioxx, has resolved most of the thousands of claims of injury by U.S. patients in a $4.85 billion settlement.

Celebrex remains as the only cox-2 inhibitor still available on the market today. According to Pfizer, state and federal courts have ruled that there is no reliable scientific evidence that Celebrex increases the risk of stroke and heart attacks. However, the FDA required all prescription non-steroidal anti-inflammatory drugs (NSAIDs), including Celebrex, to carry a “black box” warning about potential increased risk of heart attacks, stroke and gastrointestinal problems.

GD Star Rating
loading...

Originally posted 2008-10-22 11:04:09. Republished by Blog Post Promoter

Arthritis Information

My first personal experience with arthritis came from bowling. Not that bowling caused it. Just that I had it diagnosed after bowling.

I was on a church bowling team for several years and never had any problem. I didn’t throw the big curve, but had some rotation. One night my knuckles swelled up so much that the ball stuck on my hand and one time it didn’t come off at the bottom but did at the top and flew 10 feet high before striking the lane.

Needless to say, there was a doctor’s appointment as a result. He told me I had arthritis in my hands and that I should refrain from activities like bowling.

So I haven’t bowled for many years. I do participate in activities like woodworking that do cause some discomfort, but I feel fortunate that my condition is not real bad. I know others, like my former neighbor’s kids, who have severe issues with arthritis.

So how about you? When did you first discover that you had arthritis? How did it affect your life? Leave a post here.

GD Star Rating
loading...

Originally posted 2007-10-01 19:35:39. Republished by Blog Post Promoter

Related from Amazon

Archives