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The genetic connection to many types of arthritis are being discovered at a rapid pace. Now comes findings published in the New England Journal of Medicine of another genetic link rheumatoid arthritis. Two regions on Chromosome 9 have been previously identified as being linked to susceptibility and severity of RA. These are known as HLA-DRB1 and PTPN22. [...] Tumor necrosis factor (TNF) has been identified as having a key responsibility in many inflammatory diseases, including rheumatoid arthritis (RA). There has been substantial research into the early signaling pathways activated by TNF, but there is not much known about the delayed and chronic TNF responses. In addition, cells called macrophages (cells within the tissues that originate [...] Like all aspects of the development of the human body, genetics dictate each individual’s height. Last year a team of researchers identified the initial common gene that influences height. That same team has now identified 20 additional genetic regions that can collectively influence height differences of almost 2.5 inches. According to the research team, 90% of the [...] A global team of researchers, led by Professor Matthew Brown, from the University of Queensland’s Diamantina Institute for Cancer, Immunology and Metabolic Medicine, has discovered that there is a genetic relationship between ankylosing spondylitis (AS) and Crohn’s disease. The study was published in the current issue of Nature Genetics. AS is a form of arthritis that causes [...] Gout is a painful condition which results from high levels of uric acid in the blood. Over time the uric acid forms crystals in the joints which leads to inflammation, stiffness and pain. Normally, the kidneys remove uric acid from the blood and eliminate it in urine. But the kidneys in those with gout do not keep [...] |
  
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