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Researchers are not sure of the exact causes of rheumatoid arthritis (RA), but they have discovered that cytokines (bioactive proteins), in particular TNF-alpha and IL-6 are significant contributors. These cytokines cause inflammation which leads to destruction of the joints and tissues. The action of another cytokine, placenta growth factor (PIGF), is suspected to be critical for the [...] Several studies have been conducted into to effectiveness of the newest class of drugs, tumor necrosis factor (TNF)-alpha blockers, in treating rheumatoid arthritis. But there have been no published studies comparing TNF-alpha blockers with the older class of drugs, known as disease-modifying anti-rheumatic drugs (DMARDS), such as Remicade (infliximab), Enbrel (etanercept), and Humira (adalimumab). Recently a team [...] A study conducted in 2003 by the University of California, Davis was the first to test for key inflammatory indicators, called markers, in blood samples from healthy people. [...] The FDA has received 30 reports of cancer in children under the age of 18 who had been treated for JIA with anti-TNF drugs along with other medications, such as methotrexate, or similar immunosuppressant drugs. [...] A novel new drug, based on the commonly used prednisone, has been recommended for European regulatory approval for treatment of morning stiffness resulting from rheumatoid arthritis. [...] |
  
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