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Obesity May Increase Risk of Fibromyalgia

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According to a new study, women who are overweight or obese, and particularly those who do not exercise at all or exercise for less than an hour a week, have an increased risk of developing fibromyalgia.

Dr. Phil Mork and his team reviewed data from the Nord-Trondelag Health (HUNT) Study. The first HUNT study (HUNT1) was conducted in 1984 to 1986. HUNT2 was conducted from 1995 to 1997. In the 11 years of data, there were 380 new cases of fibromyalgia identified among the 15,990 women.

The researchers used the body mass index (BMI) to compare the data. BMI is calculated by dividing a person’s weight (in kilograms) by his or her height (in meters, squared). BMI can also be calculated by multiplying weight (in pounds) by 705, then dividing by height (in inches) twice. A BMI or 25 is considered overweight, over 30 is considered obese and over 40 is considered severly obese.

The HUNT studies showed that women with a BMI greater than 25 had a 60% t o70% increased risk of developing fibromyalgia compared to women with a health BMI score.

“Being overweight or obese was associated with an increased risk of fibromyalgia, especially among women who also reported low levels of leisure time physical exercise,” the researchers conclude. “Community-based measures aimed at reducing the incident of fibromyalgia should emphasize the importance of regular physical exercise and maintenance of normal body weight.”

However, the study also showed that exercise tended to offset the risk of developing fibromyalgia as a result of being overweight. The more that the women exercised the lower their risk of developing fibromyalgia. The beneficial effect of exercise was similar with those that were overweight or obese.

The researchers did not entirely understand how excess weight played into the increase in risk. However, there has been some research that suggests that increased levels of certain inflammatory proteins may play a role in both fibromyalgia and obesity.

“The results of this study underline the connection between exercise, obesity, and well-being. And a person who exercises and is conscious about their weight will have better health and that may include a lower risk of developing fibromyalgia,” says Eric Matteson, MD, chair of the department of rheumatology at the Mayo Clinic in Rochester, Minn.

The results of the study were published in the May issue of Arthritis Care & Research.

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Missouri Legislation Proposes Fibromyalgia Panel

Fibromyalgia is a disorder which results in chronic widespread pain along with debilitating fatigue, abnormal sleep patterns, bowel disturbances and cognitive dysfunction. The cause of fibromyalgia is not known, but altered function of the central nervous system is thought to be a possible cause. Genetic disposition is also a possible cause.

The Missouri General Assembly will be considering legislation to create a state fibromyalgia awareness and outreach campaign.

The bill, sponsored by Representative Shalonn Curls, of Kansas City, would require the Missouri Dept. of Health and Senior Services to appoint, convene and support a voluntary Fibromyalgia Panel. The pane would have 2 directives:

1. Raise “at least $50,000” through private funding to mount a state fibromyalgia education and outreach campaign, targeting needs such as early diagnosis & treatment and improved quality of life, and in consultation with the National Fibromyalgia Association.
2. Work with other agencies at the state and local levels to promote delivery of Fibromyalgia education and training to doctors and other healthcare professionals.
The bill would also allow doctors, and others authorized to prescribe medication, to override restrictions on medications for treatment of fibromyalgia imposed by pharmacy benefit managers – in carefully defined circumstances and “to the extent that the Panel obtains private funding for the purpose.”

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Originally posted 2008-03-03 18:37:39. Republished by Blog Post Promoter

Arthritis Primer

Arthritis is the name for a group of conditions that exhibit damage to joints such as knees, hips and fingers. According to the Arthritis Foundation there are over 100 different conditions covered by the term “arthritis”, the most common being osteoarthritis and rheumatoid arthritis.

Depending of the form of arthritis the initial symptoms of are pain and stiffness which can occur after resting (morning) or at the end of the day. Additional symptoms can include rash, fever, swelling, muscle pain, eye pain and mouth ulcers.

Osteoarthritis (OA), also known as degenerative arthritis, degenerative joint disease and arthrosis, is a condition caused by the protective cartilage that protects the ends of bones gradually breaks down. Research indicates that up to 60% of osteoarthritis cases are hereditary. It can also result from injury, obesity (additional weight on joints), inflammatory diseases, diabetes and hormonal disorders. The weight bearing joints – hips, knees and back – are most commonly affected. It is not uncommon for the joints of the feet and hands to also be affected. OA affects nearly 21 million people in the United States, accounting for 25% of visits to primary care physicians. It is estimated that 80% of the population will have some evidence of OA by age 65.

osteoarthritis image

Rheumatoid arthritis is a chronic, autoimmune disease characterized by inflammation of the synovium, or lining, of the joints. This means that the body’s immune system incorrectly identifies the synovium as a foreign material and attacks it. This results in swelling and inflammation of the joint which, in turn, causes tissue and cartilage damage around the joint.

rheumatoid arthritis image

Unfortunately, people of all ages can develop rheumatoid arthritis. Researchers have discovered many potential causes, including emotional or physical stress, bacterial infections, poor nutrition or genetics.

There are several tests that are used to diagnose rheumatoid arthritis. A blood test is used to check for the presence and level of inflammation in the body. Radiographic imaging (X-rays), magnetic resonance imaging (MRI) scans and bone scans will provide visual indications of the severity and progression of arthritis in the joints.

Following a positive diagnosis for RA, there are a number of treatment options available to slow the progression of the disease, improve the pain and maintain mobility. These treatments include several classes of drug therapies, whirlpool treatments, physical therapy and exercises to increase mobility and prevent complications.

There are also many natural treatments that can be utilized. Certain foods contain anti-inflammatory properties, such as pineapple and tart red cherries. Other foods contribute to repairing and rebuilding bone and cartilage, such as eggs, asparagus, onions and garlic. Many other foods are believed to have beneficial effects on rheumatoid arthritis symptoms. These include fish, brown rice, non-acidic fresh fruits, oatmeal, and leafy green vegetables.

Research indicates that food allergies may be linked to rheumatoid arthritis. People with rheumatoid arthritis were found to have higher antibody levels in their intestinal fluid to proteins from hen’s eggs, pork, cow’s milk, codfish and cereal than that of people without RA.

In addition, many people with back and neck pain report that they have experienced pain relief when they eliminated foods that they were allergic to.

Exercise is highly recommended for improving the symptoms of RA. Strengthening the muscles, which can contribute to a reduction of stress on the joints, leads to improved strength of the bones and improvement in the flexibility and health of the cartilage. Exercises, such as swimming or walking, are excellent ways to slow the progression of the disease.

Obesity is another common contributor to arthritis. Weight loss is one of the best ways to improve the symptoms of arthritis.

Arthritis is a serious condition. If you think that you may have arthritis, you should confer with your doctor for a diagnosis.

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Originally posted 2009-07-09 17:30:07. Republished by Blog Post Promoter

New Scan for Early Diagnosis of Osteoarthritis

Osteoarthritis is the “wear and tear” form of arthritis. It results from a breakdown of cartilage that protects the ends of the bones. Osteoarthritis is most common in the hip and knee and is the most frequent reason for total knee and hip replacement surgery.

The current methods used to diagnose osteoarthritis are ineffective prior to an advanced stage where permanent joint damage has occurred. Being able to diagnose osteoarthritis at an earlier stage could provide an opportunity to reduce or prevent permanent damage. Early in the disease it may be possible to successfully treat it with dietary supplements and medications.

Now NYU researchers Alexej Jerschow, Ph.D. and Ravinder R. Regatte, Ph.D. have developed a new scan that may provide that hoped for early diagnosis.

This new test is based on a modified form of magnetic resonance imaging (MRI). This imaging identifies the concentration of glycosaminogycan (GAG), a polymer that holds water and gives cartilage its toughness and elasticity. According to Jerschow, a low concentration of GAG is known to correlate with the inception of osteoarthritis and other cartilage disorders.

“Our methods have the potential of providing early warning signs for cartilage disorders like osteoarthritis, thus potentially avoiding surgery and physical therapy later on,” states Jerschow. “Also, the effectiveness of early preventative drug therapies can be better assessed with these methods.”

The new imaging “tags” the hydrogen atoms that are attached to the GAGs to determine the concentration of GAG in the cartilage.

“Given the lack of knowledge about OA, I think any method that is noninvasive and relatively easy to apply will be quite valuable. Not only do you address diagnosis, but you address how we can understand OA’s mechanism,” says Jerschow.

The new test could also be used to determine the efficacy of the medications used to treat osteoarthritis. In fact, pharmaceutical companies have already requested information on using the new imaging to show that their drugs work.

According to Dr. Regatte, the time and cost for the GAG scan is essentially the same as a normal MRI. It is even possible to get a diagnosis on the same day.

Drs. Jerschow and Regatte presented their findings on August 21st at the 236th National Meeting of the American Chemical Society in Philadelphia.

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Originally posted 2008-09-02 19:51:56. Republished by Blog Post Promoter

Rheumatoid Arthritis: Anti-TNF vs. DMARDS

Several studies have been conducted into to effectiveness of the newest class of drugs, tumor necrosis factor (TNF)-alpha blockers, in treating rheumatoid arthritis. But there have been no published studies comparing TNF-alpha blockers with the older class of drugs, known as disease-modifying anti-rheumatic drugs (DMARDS), such as Remicade (infliximab), Enbrel (etanercept), and Humira (adalimumab).

Recently a team of Spanish researchers, led by Dr Alberto Alonso-Ruiz has reviewed the findings of 13 clinical trials involving over 7,000 participants to compare anti-TNF to DMARDS. The team analyzed the data to determine the benefits and side effects of different doses of the drugs.

The team determined that all of the trials showed that, with the proper dose, anti-TNF were better for treating rheumatoid arthritis than drugs like methotrexate.

The research also pointed out, however, that those patients using anti-TNF drugs were more likely to complain of adverse side effects. In addition, patients that were using etanercept experienced the lowest withdrawal rates due to adverse events.

“Performing comparisons of new drugs is vital for measuring safety/efficacy relationships and monitoring adverse side-effects” said Dr. Alonzo-Ruiz.

Their research was published in the journal BMC Musculoskeletal Disorders.

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Originally posted 2008-05-02 15:36:39. Republished by Blog Post Promoter

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